Would you like to see a real, live wooly mammoth? Or how about a Tasmanian tiger in the flesh? Scientists have already finagled a few ways to resurrect extinct species from their evolutionary graves. Even muckier than the scientific methods themselves, though, are the social, ethical and legal ramifications of so-called de-extinction.
In Science today, two Stanford researchers tackle this tricky topic to parse out exactly what we have to gain and lose from de-extinction technologies. Using the passenger pigeon as a thought experiment, another paper in the same issue looks at the fears and excitement of leaders in the field of genomics.
There are three main ways of bringing back extinct species, according to the Stanford researchers: backbreeding, genetic engineering, and cloning. With backbreeding, scientists use a living species that is genetically similar to the extinct species, and selectively breed it for the traits of the now-extinct species. Genetic engineering depends on existing DNA samples of the extinct species; scientists could bring them back to life by targeting and replacing specific genomic sequences in a closely-related living species. Finally, if viable cell nuclei from the extinct species are available, it can be cloned using a technique called somatic cell nuclear transfer — a tested but as-of-yet unsuccessful method for extinct species.